Thrombogenicity causes significant complications in the application of blood-contactingimplants, requiring strategies to prevent adverse coagulation reactions. The thrombotic re-sponses to the foreign surfaces are mainly driven by surficial factors such as surface energy,topography, and electrochemical interactions. Although anticoagulation therapies reducethe risks of clotting, patients might still encounter bleeding complications. Therefore, ratherthan high-risk anticoagulation therapies to counteract coagulation, it is essential to ensurehemocompatibility through the material’s intrinsic properties. Endothelialization is crucialin preventing thrombotic complications, with various strategies explored for facilitating en-dothelial cell adhesion and proliferation. We investigated the impact of crystallographicanisotropy on endothelial and blood cell interactions on four main planes (A-, C-, M-,and R-planes) of single crystalline alumina (α-Al2O3, sapphire). Employing advanced sur-face characterization techniques, including SIMS, KPFM and Zeta potential measurements,our study sheds light on the hemocompatibility of biomaterials considering anisotropic ef-fects. We elucidated that the A-plane of alumina promotes endothelialization and suppressesplatelet activation in contrast to other crystallographic planes. Our investigation into cell-surface interactions provides valuable insights and contributes to the advanced biomaterialdesign, ultimately leading to enhanced clinical outcomes.
Parlak et al. (Thu,) studied this question.