This study presents a novel and highly efficient thin film microextraction-flow injection analysis (TFME-FIA) method utilizing a metal organic framwork-199 (MOF-199)/cellulose paper composite, coupled with high-performance liquid chromatography-UV (HPLC-UV) detection. To the best of our knowledge, this is the first report describing the application of a MOF-199-coated thin film directly integrated into an FIA system for the determination of parabens. The TFME-FIA-HPLC-UV method provides a rapid, cost-effective, and environmentally friendly approach for the determination of parabens in different types of fruit juices, honey samples and cosmetics. Under optimized conditions, the linear concentration ranges for methylparaben and propylparaben were 0.5-200 and 1.0- 500 µg L -1 , with coefficients of determination (R 2 ) of 0.9983 and 0.9990, respectively. The limits of detection (LODs) were 0.14 and 0.32 µg L -1 for methylparaben and propylparaben, respectively, while the corresponding limits of quantification (LOQs) were 0.14 and 0.46 µg L -1 and 1.0 µg L -1 . The method demonstrated good precision with relative standard deviation (RSD%) values ranging from 4.29% to 5.84%. The synergistic effect of TFME and the semi-automated FIA system resulted in enrichment factor (EF) ranging from 83 and 89 for methylparaben and propylparaben, respectively. Batch-to-batch reproducibility for three different films ranged from 5.8-6.3%. Considering the excellent performance characteristics demonstrated for the selected model parabens, which are widely used in commercial products, the proposed method can be regarded as a robust and reliable analytical system for the determination of various parabens in complex matrices, including food and cosmetic samples. • A novel MOF-199 sorbent via in-situ synthesis on cellulose paper • MOF-199 provides high stability and superior extraction capacity for parabens • This extraction phase was prepared in a specific pattern to be placed in the syringe filter • TFME coupled with FIA allow rapid, automated, and efficient extraction • High sensitivity due to excellent enrichment and minimal solvent consumption
Aliabadi et al. (Sun,) studied this question.