To evaluate the physico-chemical and biological properties of experimental hydraulic cements (EHCs) prepared after the synthesis of tricalcium silicate (C3S), calcium zirconium silicate (CZS), and strontium phosphate silicate (SPS) in comparison with Biodentine (BD). After synthesizing and characterizing the silicates (FTIR/XRD/SEM-EDS/TEM), EHCs were analyzed for setting, radiopacity, dimensional stability, compressive strength, solubility, pH, calcium/strontium ion release, and biocompatibility. Significant differences were observed in setting times, with BD3S/CZS and BD/SPS3S, both in initial and final (p CZS>C3S>BD (p 0.05). BD showed higher compressive strength than EHCs in both assessed periods (p 3S/CZS cements (p 3S (9.50; 9.23) showed higher values than SPS/BD and CZS/BD, respectively (p 3S/CZS/BD and SPS (p 3S/CZS (p 0.05); less vascularization was observed at 30 days for BD/C3S/CZS (p < 0.05). Under the study's conditions, it can be concluded that EHCs exhibited promising physicochemical properties, which can still be improved, and adequate biocompatibility. Thus, this article highlights the possibility of developing new silicate-based hydraulic cements.
Aguiar et al. (Sun,) studied this question.