What question did this study set out to answer?

The research aims to examine the relationship between high normal parathyroid hormone (PTH) levels and cardiovascular and total mortality, focusing on sex and age differences.

February 27, 2026

High Normal Parathyroid Hormone and Cardiovascular and Total Mortality: Sex and Age Disparities in the ELSA-Brasil Study

Key Points

The research aims to examine the relationship between high normal parathyroid hormone (PTH) levels and cardiovascular and total mortality, focusing on sex and age differences.
Analyzed data from a large community-based cohort (ELSA-Brasil)
Measured parathyroid hormone levels in participants
Assessed cardiovascular and all-cause mortality rates
Conducted stratified analysis by sex and age group
Elevated PTH levels correlated with increased cardiovascular mortality
The link between high PTH and mortality was significant primarily in females
Younger adults exhibited a greater risk associated with elevated PTH than older adults

Abstract

In this large, community-based cohort, PTH levels at the upper end of the reference range were associated with greater CV and all-cause mortality. The excess CV risk was restricted to females and younger adults, suggesting that PTH may serve as an early, sex-sensitive biomarker of cardiometabolic risk.

High Normal Parathyroid Hormone and Cardiovascular and Total Mortality: Sex and Age Disparities in the ELSA-Brasil Study

Key Points

Abstract

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