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Research Paper | Synapse

February 27, 2026

Diminished pleiotrophin as a new clue to pre-eclampsia: Linking impaired angiogenesis to adverse outcomes.

Key Points

Investigate the relationship between pleiotrophin levels and pre-eclampsia outcomes.
Measured maternal serum pleiotrophin levels
Assessed severity of pre-eclampsia
Evaluated perinatal outcomes in affected pregnancies
Lower pleiotrophin levels correlate with increased severity of pre-eclampsia
Decreased PTN levels linked to worse perinatal outcomes
Proposes PTN as a potential biomarker for risk assessment

Abstract

Decreased maternal serum PTN levels are associated with the presence and severity of pre-eclampsia, as well as adverse perinatal outcomes. PTN may serve as an additional angiogenic-related biomarker that complements existing diagnostic tools and improves risk stratification in pregnancies complicated by PE.

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Cite This Study

Yildirim et al. (Wed,) studied this question.

synapsesocial.com/papers/69a1352fed1d949a99abeded https://doi.org/https://doi.org/10.1002/ijgo.70907