Identification of Ferroptosis-Related Hub Genes and Immune Infiltration Landscape in Chronic Kidney Disease via Bioinformatics and Experimental Verification.

Key Points

• This research aims to identify hub genes related to ferroptosis and their role in chronic kidney disease (CKD).
• Used bioinformatics to analyze gene expression data related to CKD.
• Conducted experimental verification of identified biomarkers.
• Examined immune infiltration profiles associated with CKD progression.
• Identified NNMT, GDF15, ACSL1, DLD, NFE2L2, PARP1, and NR4A1 as significantly upregulated in CKD.
• Suggested potential of these biomarkers for CKD diagnosis and treatment.