Identifies MCT1 as the mediator of succinate release during reperfusion of the ischaemic heart, facilitated by myocardial acidification.
Succinate release upon reperfusion of the ischaemic heart is mediated by MCT1 and is facilitated by the acidification of the myocardium during ischaemia. These findings will allow the signalling interaction between succinate released from reperfused ischaemic myocardium and SUCNR1 to be explored.
Prag et al. (Tue,) studied this question.