A New Bicyclic Pyrrolidine Block for Nirmatrelvir and Analogues

Key Points

• The study aims to explore the chemical properties and applicability of a bicyclic pyrrolidine block in synthesizing Nirmatrelvir and related compounds.
• Synthesized the key block from (+)-3-carene.
• Carried out enol-ethylation of a precursor ketone under specific conditions.
• Utilized triethyloxonium tetrafluoroborate during synthesis.
• Identified key chemical properties of the bicyclic pyrrolidine block.
• Demonstrated a feasible synthesis route for Nirmatrelvir and analogues.