New Series of Pentamidine-Based 1,2,3-Triazole-Diaryl-Hydrazones: Design, Synthesis, and Evaluation of Their Leishmanicidal Activity and Mechanism of Action Against Leishmania (L.) amazonensis

Key Points

• The study aims to design and evaluate new pentamidine-based compounds for their effectiveness against Leishmania (L.) amazonensis.
• Design and synthesis of pentamidine-derived 1,2,3-triazole-diaryl-hydrazones.
• Evaluation of leishmanicidal activity using in vitro assays.
• Investigation of the mechanism of action through biochemical assays.
• Several new compounds demonstrated significant leishmanicidal activity.
• Identified mechanisms including disruption of cellular processes in Leishmania.
• Reduced cytotoxicity in mammalian cell lines compared to existing drugs.