Neural stem cells transplantation combined with ethyl stearate promotes the activation of quiescent NSCs and improves PD rats motor behavior.

Key Points

• To explore how ethyl stearate affects the activation of quiescent neural stem cells (NSCs) and motor behavior in Parkinson's disease (PD) rats.
• Transplantation of neural stem cells and ethyl stearate into PD rat models.
• Assessment of motor behavior improvements post-intervention.
• Analysis of the EphB2/AKT/CyclinD1 molecular pathway affecting NSC activation.
• Co-transplantation led to significant improvement in motor skills of PD rats.
• Activation of quiescent NSCs was observed post-treatment.
• Ethyl stearate influenced NSCs' transition to dopaminergic neurons through specific molecular pathways.