What question did this study set out to answer?

This research examines the incidence of HCC in patients with Fontan-associated liver disease and the role of AFP levels in risk assessment.

March 1, 2026Open Access

Hepatocellular carcinoma in Fontan-associated liver disease: Incidence, risk stratification, and surveillance implications

Key Points

This research examines the incidence of HCC in patients with Fontan-associated liver disease and the role of AFP levels in risk assessment.
Analyzed data on patients diagnosed with Fontan-associated liver disease
Assessed AFP levels for risk stratification
Evaluated the effectiveness of routine surveillance for HCC
Patients with elevated AFP levels faced a higher risk of HCC development
Routine surveillance improved prognosis for those who developed HCC
Prognosis for HCC patients in FALD was comparable to those without HCC

Abstract

Patients with FALD face a non-negligible risk of developing HCC, thus supporting the need for surveillance. Elevated AFP levels at the time of FALD diagnosis may aid in risk stratification, which enables the targeted monitoring and early detection of HCC. Furthermore, routine surveillance contributes to the excellent prognosis of patients with FALD who develop HCC, thus making their prognosis comparable to that of patients without HCC.

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Cite This Study

Onishi et al. (Thu,) studied this question.

synapsesocial.com/papers/69a3d8b8ec16d51705d2fc72 https://doi.org/https://doi.org/10.1097/hc9.0000000000000910

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