Alkyl enol ethers constitute valuable synthetic intermediates owing to their high nucleophilicity stemming from their electron-rich π-systems. Despite this potential, their application in organic synthesis has remained limited, largely because of the dearth of reliable methods for regioselective formation of alkyl enol ethers. Herein, we report a general one-step protocol for the regioselective synthesis of methyl enol ethers through O-methylation of kinetic enolates derived from cycloalkanones.
Prout et al. (Sat,) studied this question.
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