IgG4 surge and relapse: determining the predictive threshold for IgG4 rising kinetics in IgG4-related disease.

Key Points

• The research aims to identify a predictive threshold for IgG4 rising kinetics in IgG4-related disease (IgG4-RD).
• Monitored IgG4 levels over time
• Defined IgG4 surge as an IgG4-Ratio >1.6
• Implemented intensified treatment for patients with IgG4 surge
• Majority of seropositive IgG4-RD patients experience relapse with IgG4 surge
• Treatment adjustments can lower recurrence risk
• Dynamic monitoring of IgG4 levels is more effective than static assessments