ABSTRACT Angelito Malicse proposes three universal laws—Karma (system integrity), Balance, and Feedback Loop—as foundational principles governing complexity from cosmology to biology. This paper formalizes these into a predictive dynamical systems model, simulates evolutionary shifts toward symbiosis, and validates predictions against real-world datasets, particularly bacterial gene gain/loss and horizontal gene transfer (HGT) rates. Results show strong mechanistic alignment, supporting the framework’s utility as a heuristic for adaptive evolution.
Angelito Enriquez Malicse (Thu,) studied this question.