Knuckle Hyperpigmentation as a Sign of Vitamin B12 Deficiency | Synapse
March 2, 2026
Knuckle Hyperpigmentation as a Sign of Vitamin B12 Deficiency
Key Points
To explore the association of knuckle hyperpigmentation with vitamin B12 deficiency in a young vegetarian.
Case report of a 14-year-old vegetarian girl
Assessment of skin pigmentation symptoms
Monitoring of dietary habits
Progressive pigmentation observed on hands and feet
No gastrointestinal or neurological symptoms reported
Abstract
A 14-year-old vegetarian girl presented with a one-year history of progressive pigmentation on her hands and feet, without gastrointestinal or neurological symptoms.