Introduction- Granules (khanda kalpana) are the modified dosage form of Avaleha kalpana (Confections) where the ratio of sugar is altered in content and final product as well with reducing moisture content in the final product. A standard granular dosage form is very easy for dispensing and has more self-life with uncompromising therapeutic potency, in comparison to the avaleha dosage form of the same ingredients. Aim and Objective: In the current research work, it is tried to characterize the said granule in terms of its physico-chemical analysis for developing fingerprint data for its rational, safe clinical use. Methodology: The current research at first the Kantakaryadi granules is manufactured by modifying the pharmaceutical processing of Kantakaryadi avaleha, by following the working principles of Avaleha kalpana and khanda kalpana, thereafter. Then the prepared Kantakaryadi granules are analyzed by following the modern scientific analytical techniques like HPTLC study, Phytochemical analysis, Total ash Value, pH value etc. for generating the fingerprint data. Observation and Discussion: In the said research the analytical findings reveal that it contains alkaloids, glycosides, tannins and carbohydrates in significant amounts whereas flavonoids, steroids and terpenoids are also found in the sample. It is lacking saponins, proteins and starch, having pH- 5.99 and 38.74% sugar. The analytical data suggests its comfortable rational use in human beings with additional benefit of enhanced self-life, appropriate palatability, easy storing and transportation along with convenience of drug delivery and drug dispensing system, in comparison to the same avaleha. Summary and Conclusion: Kantakaryadi granule is a noble solid dosage form and physico-chemically suitable for rational therapeutic use. All the analytical data observed are within the normal range of human use for therapeutic purposes. The data generated for Physico-chemical characterization could be the finger print standard for Kantakaryadi granules for further research in academics and industries.
Harshit Baranwal1*, Himanshu2, Sudhaldev Mohapatra3 (Sun,) studied this question.