Post-eradication fecal homovanillic acid levels are strongly associated with long-term symptom improvement and anti-inflammatory responses in H. pylori-associated FD patients. Higher HVA levels measured 8-10 weeks after eradication therapy reflect successful microbiota recovery and are associated with favorable clinical outcomes at 12 months. These findings suggest that fecal HVA may serve as a prognostic biomarker for identifying patients who will achieve sustained therapeutic benefits following H. pylori eradication, potentially guiding post-treatment monitoring strategies and personalized interventions to optimize gut microbiota recovery..
Hongjun Zhou (Sat,) studied this question.