SeDeM and Powder flow tools-assisted design of solid SMEDDS of luliconazole for antifungal therapy.

Key Points

• This research aims to develop a solid self-microemulsifying drug delivery system (SMEDDS) for luliconazole to improve its effectiveness against fungal infections.
• Utilized S-SMEDDS platform for formulation development
• Assessed solubility and stability of luliconazole
• Evaluated transdermal delivery effectiveness
• Achieved enhanced solubility of luliconazole
• Improved transdermal delivery performance
• Demonstrated formulation stability suitable for industrial production