Chlorpyrifos-induced autism and depression-like behaviors are ameliorated by trehalose: Integrating network pharmacology and toxicology analyses and animal experiments

Key Points

• Chlorpyrifos exposure leads to significant depression-like behaviors in animal models, indicating a strong association.
• Animal experiments reveal that trehalose treatment significantly reduces these behaviors by altering related biomarkers.
• Analysis integrates network pharmacology and toxicology to explore the underlying mechanisms and effects of trehalose.
• These findings hint at new therapeutic strategies for managing chlorpyrifos-related behavioral issues in vulnerable populations.