Resveratrol alleviated diabetic retinal neuronal ferroptosis induced by high glucose through inhibiting HIF-1α and HMOX1 pathway

Key Points

• Resveratrol treatment significantly reduces retinal neuronal ferroptosis, which is critical in diabetic retinopathy.
• A reduction in HIF-1α and HMOX1 levels support these findings, as they are involved in oxidative stress pathways.
• Analysis of retinal neurons under high glucose conditions revealed increased ferroptosis, which resveratrol mitigates.
• These results may suggest a new therapeutic approach for preventing retinal damage in diabetes, but further studies are needed.