Effects of chloromethylisothiazolinone/methylisothiazolinone on cytotoxicity and mitochondrial dysfunction in bronchial epithelial cells

Key Points

• Cytotoxicity is induced in bronchial epithelial cells due to exposure to chloromethylisothiazolinone and methylisothiazolinone, highlighting a potential hazard.
• Key evidence shows that mitochondrial dysfunction is associated with cellular damage, affecting cell survival and respiratory function.
• The analysis employed in vitro techniques to observe the effects on bronchial epithelial cells under varying concentrations of the chemical agents.
• These findings underline the need for further evaluation of the safety of chloromethylisothiazolinone and methylisothiazolinone in consumer products.