Integrated proteomic profiling of aqueous humor reveals CDC42/RHOA-mediated pathogenic mechanisms in nAMD and PDR

Key Points

• The study identifies cdc42 and rhoa as key pathways in the pathogenesis of neovascular age-related macular degeneration.
• Proteomic profiling of aqueous humor shows significant alterations in patients with proliferative diabetic retinopathy.
• Analysis involved comprehensive proteomic methods to uncover disease mechanisms linked to eye disorders.
• The findings suggest potential new avenues for targeted therapies in eye diseases based on identified molecular pathways.