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A protective role of ECSIT in chemotherapy-induced intestinal mucositis by maintaining Lgr5+ intestinal stem cells and gut homeostasis | Synapse
March 3, 2026
A protective role of ECSIT in chemotherapy-induced intestinal mucositis by maintaining Lgr5+ intestinal stem cells and gut homeostasis
SW
Shuai Wang
YJ
Yuying Jiang
JY
Jie Yu
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Key Points
ECSIT maintains gut homeostasis by protecting Lgr5+ intestinal stem cells during chemotherapy-induced mucositis.
In this analysis, patients undergoing chemotherapy showed reduced mucositis severity with ECSIT activity.
Assessment used biochemical markers to evaluate the status of intestinal stem cells and mucosal integrity.
Findings highlight ECSIT as a key factor in mediating intestinal health, suggesting therapeutic avenues in chemotherapeutic interventions.
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Wang et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75a68c6e9836116a202d2
https://doi.org/https://doi.org/10.1016/j.lfs.2026.124236