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March 3, 2026
Open Access
Protocol for the generation and xenotransplantation of human induced pluripotent stem cell-derived neural progenitor cells into the mouse forebrain
JM
Julie J. McInvale
CA
Chloe E. Ayers
HS
Hemanta Sarmah
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Key Points
Neural progenitor cells derived from human induced pluripotent stem cells will be xenotransplanted into mouse forebrains.
Protocol aims to standardize the generation and implantation processes over a timeframe yet to be specified.
Trial protocol for creating human stem cells and implementing them into a mouse model.
If successful, it may inform future therapeutic approaches in treating neurological disorders.
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Protocol for the generation and xenotransplantation of human induced pluripotent stem cell-derived neural progenitor cells into the mouse forebrain | Synapse
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McInvale et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75a87c6e9836116a20736
https://doi.org/https://doi.org/10.1016/j.xpro.2025.104305