Background Liver Fibrosis as a Microenvironmental Risk Factor for Intrahepatic Recurrence in Colorectal Liver Metastases

Key Points

• Intrahepatic recurrence is more prevalent in cases with liver fibrosis, suggesting a vital link between fibrosis and cancer outcomes.
• The findings show a notable increase in recurrence among patients with liver fibrosis, underscoring its role as a risk factor.
• Observational analysis evaluated the influence of the microenvironment on colorectal liver metastases and their recurrence.
• Understanding liver fibrosis as a microenvironmental risk factor highlights the need for tailored therapeutic approaches.