In vitro evidence shows that noradrenaline, adrenaline, and amiodarone strongly inhibit human catalase, which may explain some of their clinical side effects.
Noradrenaline, adrenaline, and amiodarone hydrochloride have strong inhibitory effects on catalase activity. Catalase inhibition may be responsible for the side effects of these drugs. Therefore, when these drugs are used in treatment, their dosages and duration of administration should be carefully controlled to prevent adverse effects due to catalase enzyme inhibition.
Argan et al. (Mon,) studied this question.