March 3, 2026Gastroenterology Research and Practice0 citationsOpen Access

Clinical Characteristics of Late‐Onset (≥ 65 Years) Ulcerative Colitis: A Single‐Center Retrospective Study

AIAyumi ItoTokyo Women's Medical University MKMiki KorokuTokyo Women's Medical University SMSyun MurasugiTokyo Women's Medical University

Key Points

Remission rates for late-onset ulcerative colitis were found to be low, indicating treatment resistance over time.
The analysis observed surgical rates increase with older age, raising concerns about the disease's severity.
Steroid-related side effects also reportedly increase with age, complicating management of late-onset cases.
Potential differences in the pathogenesis of late-onset ulcerative colitis highlight the need for tailored treatment approaches.

Abstract

In conclusion, remission rates were low and surgical rates were higher with increasing age of onset. In addition, steroid-related side effects increased with age. It was possible that late-onset UC may have a different pathogenesis and be resistant to treatment.

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