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ShortCut RNase III is capable of digesting single mRNA transcripts into < 10 nucleotide products | Synapse
March 3, 2026
ShortCut RNase III is capable of digesting single mRNA transcripts into < 10 nucleotide products
KT
Kyle J. Tynan
National Institute of Standards and Technology
ML
Mark S. Lowenthal
KS
Karndeep Singh
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Key Points
Efficient digestion of single mRNA transcripts results in products under 10 nucleotides.
Key evidence shows that ShortCut RNase III exhibits high nuclease activity on mRNA transcripts, yielding small products.
Analysis of nuclease activity demonstrated that the enzyme digests mRNA efficiently into short nucleotides.
Potential applications in molecular biology highlight the need for precise mRNA processing tools.
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Cite This Study
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Tynan et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75ad9c6e9836116a213a3
https://doi.org/https://doi.org/10.1016/j.biochi.2026.01.012