• BPA exposure elevated cardiac troponin, creatinine kinase, lactate and lactate dehydrogenase • BPA also altered Na + /K + -ATPase and Ca 2+ -ATPase activities and cardiac histology • These events were accompanied by oxidative stress and inflammation • CoQ10 attenuated BPA-induced derangements Bisphenol A is an endocrine disruptor widely used by humans, and has diverse toxic effects, such as cardiotoxicity. The cardiotoxic effect of Bisphenol A is multifaceted and includes the depletion of cellular antioxidants and impairment of Na + /K + -ATPase and Ca 2+ -ATPase activities. On the other hand, Coenzyme Q10 exerts cardioprotection through its antioxidant activities. However, little to nothing has been reported on the cardioprotective effect of Coenzyme Q10 against Bisphenol A-induced cardiotoxicity. The current study explored the impact of Coenzyme Q10 on Bisphenol A -induced cardiotoxicity. Additionally, the involvement of cellular antioxidants and Na + /K + -ATPase and Ca 2+ -ATPase activities were investigated. Twenty-four adult male Wistar rats were randomized to four equal groups. The control had 0.5 mL/day of corn oil, while the Coenzyme Q10-treated had 10 mg/kg/day of Coenzyme Q10, Bisphenol A-treated had 50 mg/kg/day of Bisphenol A, and Bisphenol A+ Coenzyme Q10-treated rats had 50 mg/kg/day of Bisphenol A and 10 mg/kg/day of Coenzyme Q10 for 4 weeks. Bisphenol A significantly increased cardiac injury markers (troponin, creatinine kinase, lactate, and lactate dehydrogenase). Bisphenol A also altered cardiac histology as depicted by the presence of focal hemorrhage, inflammatory cell infiltration, reduced myofibril thickness, increased intercellular space, reduced nuclei width, and length, reduced total nuclei density, and increased pyknotic nuclei and amyloid accumulation. These findings were accompanied by oxidative stress (elevated malondialdehyde and reduced glutathione, catalase, and superoxide dismutase), inflammation (elevated myeloperoxidase activity), impaired cardiac Na + /K + -ATPase and Ca 2+ -ATPase activities and increased cardiac DNA fragmentation. These biochemical and histological perturbations induced by Bisphenol A exposure were attenuated by Coenzyme Q10 co-administration. In conclusion, the present study demonstrated that Coenzyme Q10 attenuated Bisphenol A-induced cardiotoxicity by maintaining cellular antioxidant levels and activities and improving Na + /K + -ATPase and Ca 2+ -ATPase activities.
Saka et al. (Tue,) studied this question.