March 3, 2026Open Access

Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness

Key Points

Shared pleiotropic loci link aging with muscle weakness, revealing genetic factors involved.
Notable genes identified include APOC1 and TOMM40 for longevity, alongside DYM and TGFA for muscle weakness.
Identifying susceptibility genes used genomic data to highlight their roles in aging-related phenotypes.
These findings improve understanding of genetic factors affecting long-term health and can inform interventions.

Abstract

We identified susceptibility genes for longevity (APOC1, TOMM40) and muscle weakness (DYM, TGFA) and uncovered shared pleiotropic loci linking aging and muscle decline. These findings improve the understanding of the genetic architecture underlying aging-related phenotypes and provide potential molecular targets for promoting healthy aging and reducing late-life disability.

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Cite This Study

Lin et al. (Mon,) studied this question.

synapsesocial.com/papers/69a75b3bc6e9836116a22342 https://doi.org/https://doi.org/10.1002/jcsm.70197

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