Global burden of schizophrenia in 204 countries and regions from 1990 to 2021 and machine learning-based projections to 2036: an analysis of the 2021 global burden of disease study

Key Points

• The projections indicate that while the global age-standardized incidence rate may decline, prevalence and disability-adjusted life years are expected to rise.
• Findings show a significant correlation of schizophrenia metrics with both gender and socio-demographic index across various regions.
• Assessment using machine learning-based projections suggests an increase in the overall burden of schizophrenia through 2036.
• The escalating global challenge highlights the need for enhanced mental health interventions and resources in diverse countries.