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SIRT3-dependent enhancement of apelinergic signaling mediates the cardioprotective effects of late-life high-intensity interval training | Synapse
March 3, 2026
Open Access
SIRT3-dependent enhancement of apelinergic signaling mediates the cardioprotective effects of late-life high-intensity interval training
QL
Qiaowei Li
YS
Yanmei Song
QL
Qin Liu
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Key Points
Cardioprotection is significantly enhanced through the SIRT3 pathway, improving heart health.
Reports indicate a 30% increase in apelin levels following high-intensity interval training in older adults.
Analysis of metabolic pathways reveals the crucial role of SIRT3 in mediating these effects.
These findings highlight the potential for exercise interventions to improve heart health in later life.
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Li et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75b67c6e9836116a22aab
https://doi.org/https://doi.org/10.1016/j.jphyss.2026.100061