March 3, 2026Open Access

Efficacy, adherence, and cost-efficiency of three growth hormone treatment strategies in children with idiopathic short stature: a retrospective cohort study

Key Points

Sequential therapy demonstrates effective adherence and cost-efficiency for treating idiopathic short stature.
This approach reduces costs while maintaining efficacy compared to long-acting and short-acting therapies.
Assessment of treatment strategies involved a retrospective cohort of children with idiopathic short stature.
Future work may highlight the importance of quality-of-life assessments in determining cost-effectiveness.

Abstract

Sequential therapy offers efficacy and compliance benefits for long-acting rhGH while lowering costs, thus making it suitable for ISS treatment. Long-acting therapy is ideal for individuals with the financial means to support such treatment, whereas short-acting therapy is an option for individuals facing budgetary constraints. Future research should include longer follow-up and quality-of-life (QoL) assessments to improve the cost-benefit analysis.

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Cite This Study

Jie et al. (Tue,) studied this question.

synapsesocial.com/papers/69a75b90c6e9836116a230af https://doi.org/https://doi.org/10.1515/jpem-2025-0573

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