Structure-based insights into novel alkylated pyrrole and flavonoid from Dracaena reflexa as potential inhibitors of SARS-CoV-2 main and spike protease with ADME analysis | Synapse
March 3, 2026Open Access
Structure-based insights into novel alkylated pyrrole and flavonoid from Dracaena reflexa as potential inhibitors of SARS-CoV-2 main and spike protease with ADME analysis
Key Points
Alkylated pyrrole and flavonoids show significant inhibition against SARS-CoV-2 main and spike protease, highlighting their potential as therapeutic agents.
Binding affinity measurements reveal promising interactions with target proteases that may support the development of effective treatments.
Assessment of ADME (absorption, distribution, metabolism, and excretion) properties indicates favorable profiles for lead compounds from Dracaena reflexa.
Findings underline the importance of natural compounds in antiviral drug discovery, potentially guiding future research efforts.