March 3, 2026Open Access

Tanshinone IIA prevents septicemia acute kidney injury via regulating the DUSP10/JNK/P38/NLRP3 pathway

Key Points

Tanshinone IIA mitigates inflammation, leading to protective effects against acute kidney injury.
The modulation of the DUSP10/JNK/P38/NLRP3 pathway is crucial for its beneficial effects.
The analysis suggests that tanshinone IIA may serve as a therapeutic strategy for septicemia-induced acute kidney injury.
Further investigation is warranted to confirm its efficacy and safety in clinical settings.

Abstract

Tanshinone IIA exerts a protective effect against SA-AKI by mitigating inflammation and apoptosis. Mechanistically, these effects appear to be mediated through DUSP10 and modulation of the JNK/P38/NLRP3 pathway. These findings suggest that tanshinone IIA might be a potential therapeutic strategy for SA-AKI.

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Discussion

Authors

Dan Wen

Nanchang University

Journals

American Journal of Translational Research

Actions

Institutions

Nanchang University

First Affiliated Hospital of Nanchang University

First Affiliated Hospital of Jiangxi Medical College

References and Citations

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Building similarity graph...

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Tanshinone IIA prevents septicemia acute kidney injury via regulating the DUSP10/JNK/P38/NLRP3 pathway

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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