Elevated interstitial fluid pressure promotes spheroid growth and reduces CAR-T therapeutic efficacy in solid tumors

Key Points

• Spheroid growth is significantly promoted by elevated interstitial fluid pressure, impacting tumor response.
• A decline in CAR-T therapeutic efficacy is observed as interstitial fluid pressure increases in solid tumors.
• Analysis across various tumor types indicates that pressure alters the tumor microenvironment, influencing treatment outcomes.
• These findings suggest a need for strategies to manage interstitial pressure to improve CAR-T efficacy, highlighting a critical barrier.