The rheumatoid arthritis citrullinome is enriched in antigenic complement proteins

Key Points

• Enrichment of antigenic complement proteins correlates with rheumatoid arthritis severity and autoimmunity.
• Key evidence shows a notable increase in complement proteins linked to citrullinated peptides in patients.
• Observational analysis highlights the citrullinome's role in autoimmune responses within rheumatoid arthritis.
• Findings suggest potential targets for future therapies and emphasize new autoimmunity pathways.