Medial temporal lobe atrophy is associated with age and pathologies, especially small vessel disease

Key Points

• Medial temporal lobe atrophy correlates strongly with aging, indicating potential diagnostic value in elderly populations.
• Notably, small vessel disease shows a significant association with medial temporal lobe changes, highlighting a common pathway in pathology.
• The analysis employed imaging methods to assess brain structures in different age groups and disease states across various subjects.
• Findings indicate the need for further investigations to clarify these associations and their implications for clinical practice.