MICALL2 promotes angiogenesis of colorectal cancer by regulating the EGFR/PI3K/AKT/KLF5/VEGFA axis

Key Points

• Angiogenesis is significantly influenced by MICALL2 through regulation of key molecular pathways.
• The study identifies the EGFR/PI3K/AKT/KLF5/VEGFA axis as central to this process.
• Proinflammatory cytokines may also modulate this signaling, affecting cancer blood vessel growth.
• Understanding this pathway highlights potential therapeutic targets for colorectal cancer treatment.