Leptin receptor rs1137101 polymorphism and altered leptin-sOb-R axis contribute to type 2 diabetes risk in Gujarat population
Key Points
Elevated leptin levels may contribute to increased susceptibility to type 2 diabetes.
The study shows significant associations with the LEPR rs1137101 polymorphism and diabetes risk.
Analysis assesses genetic variations alongside protein levels of sOb-R in the population.
Findings suggest potential for targeted interventions based on genetic predisposition.
Abstract
The LEPR rs1137101 A/G polymorphism, together with elevated leptin, and decreased sOb-R protein levels, may increase susceptibility to T2D in the Gujarat population.
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Leptin receptor rs1137101 polymorphism and altered leptin-sOb-R axis contribute to type 2 diabetes risk in Gujarat population | Synapse