Genome-wide investigation highlights global and local pleiotropy linking neurodevelopmental disorders to acquired hearing problems
Key Points
Comorbidity between neurodevelopmental disorders and acquired hearing problems indicates shared mechanisms.
Evidence reveals that both intrinsic and extrinsic factors contribute to the observed relationships.
Analysis highlights potential genetic links through genome-wide approaches, emphasizing pleiotropy.
Shared pathogenic processes may inform future strategies for intervening in both disorder types.
Abstract
Our findings provide evidence that the comorbidity between neurodevelopmental disorders and HP is at least partially due to shared pathogenic processes acting through intrinsic and extrinsic factors.