Rhein Inhibits NLRP3 Activation and Alleviates Microglial Pyroptosis After Intracerebral Hemorrhage in Rats | Synapse
March 3, 2026Open Access
Rhein Inhibits NLRP3 Activation and Alleviates Microglial Pyroptosis After Intracerebral Hemorrhage in Rats
Key Points
Rhein alleviates neurological dysfunction by reducing microglial pyroptosis and mitigating neuroinflammation after intracerebral hemorrhage.
The most significant finding shows decreased NLRP3 inflammasome activation in the treatment group, linked to improved symptoms.
Assessment using a rat model of intracerebral hemorrhage shows that rhein administration leads to notable recovery signs.
These findings may enable further exploration of rhein's therapeutic potential in treating neuroinflammatory conditions.
Abstract
Rhein alleviates neurological dysfunction following ICH by inhibiting NLRP3 inflammasome activation, reducing microglial pyroptosis, and mitigating neuroinflammation.