March 3, 2026Open Access

Prognostic Implications of Left Ventricular Ejection Fraction Improvement in Patients with Heart Failure with Reduced and Mildly Reduced Ejection Fraction.

Key Points

Improvement in left ventricular ejection fraction is a key prognostic indicator for heart failure.
A higher LVEF at 6 months correlates with better patient outcomes over time.

Structured PICO

Does higher-dose fundamental HF therapy improve prognosis more than achieving a higher overall GDMT score in patients with HFrEF and HFmrEF?

Population

Patients with Heart Failure with Reduced and Mildly Reduced Ejection Fraction

Intervention

Higher-dose fundamental HF therapy

Comparator

Achieving a higher overall GDMT score

Outcome

Prognosis

In patients with HFrEF and HFmrEF, achieving higher doses of fundamental HF therapies may be more prognostically important than simply increasing the overall number of GDMT classes prescribed.

Abstract

LVEF trajectory at 6 months appears to be a valuable prognostic tool, and higher-dose fundamental HF therapy was more important than achieving a higher overall GDMT score.

Prognostic Implications of Left Ventricular Ejection Fraction Improvement in Patients with Heart Failure with Reduced and Mildly Reduced Ejection Fraction.

Key Points

Structured PICO

Abstract

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