ClC-2 channels mediate hypotonicity-induced aldosterone production in adrenal zona glomerulosa cells via chloride outflow and subsequent depolarization.
ClC-2 plays a role in the ZG's response to reduced extracellular osmolality through chloride outflow, which likely causes depolarization, voltage-dependent calcium influx, and aldosterone production. These data advance our understanding of regulators of aldosterone production.
Volkert et al. (Wed,) studied this question.