Itaconate-based nanoparticles induce immunometabolic reprogramming in macrophages and alleviate diet-induced obesity

Key Points

• Itaconate nanoparticles alleviate diet-induced obesity, promoting reprogramming in macrophages and improving metabolic status.
• A significant reduction in body weight by 20% was observed in treated mice after four weeks.
• Assessment using itaconate-based nanoparticle delivery showed substantial effects on immunometabolic processes.
• These findings highlight a promising approach for obesity management, although further studies are needed for validation in humans.