Fifteen years of the Diversity Outbred mouse model: a review

Key Points

• The diversity outbred mouse model demonstrates significant genetic variation, crucial for studying complex traits.
• Over 15 years, the model has revealed new phenotypic traits that support understanding of genetic diversity.
• Observational analysis of the genetic and phenotypic data highlights advantages over traditionally inbred mice.
• This model enables progress in translational research, but variations might limit broad applicability.