Clinical and Radiographic Factors Associated With Difficult‐to‐Manage Axial Spondyloarthritis: A Multicenter Study

Key Points

• Difficult-to-manage axial spondyloarthritis shows a significant clinical and radiographic burden in affected individuals and indicates a need for effective treatment strategies.
• Patients with a history of anterior uveitis or peripheral arthritis are more likely to experience challenging symptoms, emphasizing the complexity of their conditions.
• Analysis conducted across multiple centers reveals the importance of considering comorbidities and smoking history when treating axial spondyloarthritis.
• Findings highlight the necessity for optimized treatment strategies to improve outcomes, particularly in individuals with complex health profiles.