March 3, 2026

Lipoprotein(a) selectively associates with vulnerable coronary plaque phenotypes in comparison with other established risk markers

Key Points

High-risk coronary plaques relate to elevated lipoprotein(a) levels in asymptomatic individuals, indicating a potential marker for vulnerability.
Lp(a) association demonstrates its unique role compared to traditional risk enhancers in coronary plaque characterization.
Assessment involved evaluating coronary plaque features in asymptomatic primary prevention patients for cardiovascular risk.
Findings support enhanced risk stratification strategies, underscoring the need for considering Lp(a) in clinical evaluations.

Abstract

In asymptomatic primary prevention patients, Lp(a) was independently associated with high-risk coronary plaque features, specifically LDNCP, beyond traditional risk enhancers. These findings highlight the unique role of Lp(a) in identifying coronary plaque vulnerability and suggest complementary roles for Lp(a) and CAC in refining cardiovascular risk stratification.

Lipoprotein(a) selectively associates with vulnerable coronary plaque phenotypes in comparison with other established risk markers

Key Points

Abstract

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