March 3, 2026Open Access

The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer

Key Points

JAML deficiency may lead to disrupted cGAS-STING pathway activation, impacting cancer progression.
Clinically, JAML expression could serve as an important biomarker for predicting treatment response in patients.
Assessment of JAML's role was performed with a focus on immune microenvironment changes during cancer progression.
These findings support the potential for developing tailored immunotherapy strategies in endometrial cancer.

Abstract

These findings suggest that JAML deficiency may suppress cyclic GMP-AMP synthase (cGAS)-STING pathway activation, potentially contributing to M1/M2 macrophage polarization imbalance and facilitating EC progression. Clinically, JAML expression shows promise as a potential biomarker for prognostic stratification and treatment response prediction (chemotherapy/immunotherapy), providing insights for developing precision immunochemotherapy strategies in EC.

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Tian et al. (Thu,) studied this question.

synapsesocial.com/papers/69a75d7fc6e9836116a279a5 — DOI: https://doi.org/10.3389/fimmu.2026.1738596

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Authors

Chenfan Tian

The Affiliated Yongchuan Hospital of Chongqing Medical University

Yuanyang Yao

Peking University

Yuan Tu

The Affiliated Yongchuan Hospital of Chongqing Medical University

Journals

Frontiers in Immunology

Actions

Institutions

Peking University

Chongqing Medical University

Peking University People's Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Also consider