MicroRNA-374b-5p suppresses osteosarcoma progression via the PDPK1-mediated AKT pathway | Synapse
March 3, 2026Open Access
MicroRNA-374b-5p suppresses osteosarcoma progression via the PDPK1-mediated AKT pathway
Key Points
Osteosarcoma progression is significantly inhibited by miR-374b-5p upregulation, indicating its therapeutic potential.
Key metric highlights include miR-374b-5p targeting PDPK1 and effectively modulating the AKT pathway activity.
Analysis of miR-374b-5p expression in osteosarcoma reveals its low levels and capacity to suppress tumor growth.
These findings support the relevance of the AKT pathway in osteosarcoma, emphasizing the need for further investigations.
Abstract
MiR-374b-5p was lowly expressed in OS, and its upregulation inhibited the progression of OS by directly targeting PDPK1 to affect the activity of the AKT pathway.